Pharmaceutical agents affecting metabolism; Pharmaceutical preparations acting on the central nervous system; Pharmaceutical preparations and substances for the treatment of viral, metabolic, endocrine, musculoskeletal, cardiovascular, cardiopulmonary, genitourinary, sexual dysfunction, oncological, hepatological, ophthalmic, respiratory, neurological, gastrointestinal, hormonal, dermatological, psychiatric and immune system related diseases and disorders; Pharmaceutical preparations for the prevention of as well as management, diagnosis and prognosis of autoimmune, inflammatory, metastatic, hematologic, oncologic, neurologic and metabolic diseases, conditions, and disorders, and diseases, conditions, and disorders associated with misfolded proteins, and diseases, conditions and disorders affecting the systemic and central nervous system.; Pharmaceutical preparations for the treatment and prevention of as well as management, diagnosis and prognosis of the following specific list of enumerated indications: autoimmune, inflammatory, metastatic, hematologic, oncologic and neurologic diseases, conditions and disorders, and diseases, conditions and disorders associated with misfolded proteins, and diseases, conditions and disorders affecting the central nervous system, and psoriasis, psoriatic arthritis, rheumatoid arthritis, dermatitis, host/graft rejections, Alzheimer's and Parkinson's-disease, insulin resistance, systemic metabolic disorders, hereditary cerebral hemorrhage with amyloidosis of the Dutch type, dementia pugilistica /chronic traumatic encephalopathy, inclusion body myositosis, mild cognitive impairment, chronic inflammation, Familial Mediterranean Fever, plasma cell (B-cell) dyscrasias, prion diseases, dialysis related amyloidosis and carpal tunnel syndrome, senile cardiac amyloidosis, Familial Amyloidotic Polyneuropathy, medullary carcinoma of the thyroid and type II diabetes